Is iNOS Beginning to Smoke?
نویسنده
چکیده
Inducible nitric oxide synthase (iNOS) helps drive numerous inflammatory disorders, but its inhibition has not had therapeutic success. Now Seimetz et al. (2011) make a case for inhibiting iNOS in an effort to treat one of the world's leading causes of death-chronic obstructive pulmonary disease.
منابع مشابه
Effect of exposure to cigarette smoke on carotid artery intimal thickening: the role of inducible NO synthase.
OBJECTIVE We investigated the role of inducible NO synthase (iNOS) in intimal thickening with exposure to cigarette smoke (CS). METHODS AND RESULTS Intimal thickening in wild-type (WT) and iNOS-deficient (iNOS-/-) mice subjected to CS exposure was induced by placement of a cuff around the carotid artery. CS exposure in WT mice was associated with increased arterial iNOS expression, superoxide...
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ورودعنوان ژورنال:
- Cell
دوره 147 شماره
صفحات -
تاریخ انتشار 2011